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abrilumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ITGA4+ITGB7 Therapeutic Antibody TAB-H02 1mg Please Inquiry
Product Detail
Cat
TAB-H02
Product Overview
Recombinant human antibody to Human ITGA4+ITGB7
Type
IgG2 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
CAS
1342290-43-0
Specificity
ITGA4_ITGB7(integrin alpha4 (CD49d)_beta7, integrin alpha4_beta7, integrin α4β7, lymphocyte Peyer s patch adhesion molecule 1, LPAM-1) [Homo sapiens]
Protein Construction
gamma2 heavy chain (1-444) [Homo sapiens VH – (IGHD) – IGHJ5*02) [8.8.11] (1-118) -IGHG2*01 (CH1 (119-216), hinge (217-228), CH2 (229-337),CH3 (338-442), CHS (443-444)) (119-444)], (132-214') – disulfide withkappa light chain (1'-214') [Homo sapiens V-KAPPA (IGKV1-12*01 (95.80%) – IGKJ1*01) [6.3.9] (1'-107') – IGKC*01 (108'-214')]; dimer (220-220'':221-221'':224-224'':227-227'') – tetrakisdisulfide
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Background
Introduction
Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins in turn trigger chemical pathways to the interior (signal transduction), such as the chemical composition and mechanical status of the ECM, which results in a response (activation of transcription) such as regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane
Keywords
ITGA4; ITGB7; Integrin α4β7; CD49d/β7
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