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abituzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ITGAV Therapeutic Antibody TAB-H01 1mg Please Inquiry
Product Detail
Cat
TAB-H01
Product Overview
Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.
Type
IgG2 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, western blot, immunohistochemistry, flow cytometry, immunoaffinity purification and most other immunological methods. ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
CAS
1105038-73-0
Specificity
ITGAV (integrin alpha V, CD51) [Homo sapiens]
Protein Construction
gamma2 heavy chain (1-447) with IGHG1 hinge region [humanized VH (Homo sapiens IGHV1-46*01 (77.30%) – (IGHD) – IGHJ6*01) [8.8.11] (1-118)– Homo sapiens IGHG (IGHG2*03 CH1 (119-216), IGHG1 hinge C5>S (221) (217-231), IGHG2*03 CH2 F84.3>A (296), N84.4>Q (297) (232-340), CH3(341-445), CHS (446-447)) (119-447)], (132-214') – disulfide withkappa light chain (1'-214') [humanized V- KAPPA (Homo sapiens IGKV1-33*01 (86.30%) – IGKJ2*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01(108'-214')]; dimer (227-227":230 -230") – bisdisulfide
Purity
Purity >95% by SDS-PAGE.
Background
Antigen Description
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
Function
contributes_to insulin-like growth factor I binding; contributes_to opsonin binding; protein binding; protein kinase C alpha binding; contributes_to protein kinase C binding; receptor activity; transforming growth factor beta binding;
Gene ID
3685
Synonyms
ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; VNRA; VTNR; DKFZp686A08142;
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