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Talizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IgE Fc Therapeutic Antibody TAB-886 1mg Please Inquiry
Product Detail
Cat
TAB-886
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human IgE Fc. Talizumab is a humanized monoclonal antibody as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils.
Target
IgE Fc
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
380610-22-0
Molecular Weight
Approximately 150 kDa
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
Immunoglobulin E (IgE) is a class of antibody (or immunoglobulin (Ig) "isotype") that has been found only in mammals. IgE exists as monomers consisting of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as parasitic worms like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica. IgE may also be important during immune defense against certain protozoan parasites such as Plasmodium falciparum.
Keywords
IgE Fc; IgE; Immunoglobulin E; Immunoglobulin E Fc
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