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Anti-IGHG1 Protein A Scaffold, Biotin-Conjugated

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IgG Protein A scaffold, Biotin-Conjugated AFB-32LY 1mg Please Inquiry
Product Detail
Cat
AFB-32LY
Product Overview
The Anti-IgG Protein A Scaffold molecule binds with high affinity to human IgG of IgG1, IgG2 and IgG4 subclasses which comprise 92-98% of total IgG in a normal individual. The Anti-IgG Protein A Scaffold molecule is well suited for affinity chromatography, depletion of IgG from human serum, and can be used as a detection reagent in a variety of assays. The Biotin-Conjugated Anti-IgG Protein A Scaffold molecule is biotinylated at a unique C-terminal cysteine using a maleimide-biotin reagent, facilitating immobilization on various streptavidin coated solid supports.
Species Reactivity
human
Expression Host
E. coli
Applications
Affinity Chromatgraphy.
Specificity
Anti-IgG Protein A scaffold molecule binds to the Fc part of IgG from several species; human; mouse; rabbit and monkey (Rhesus) with similar binding preferences as Protein A in terms of sub-class specificities.
Molecular Weight
14.6 kDa
Storage
Short-term storage at +4°C is recommended. For long-term storage, the protein solution should first be aliquoted and stored frozen at -20°C.
There is no decrease in performance of the biotinylated Protein A Scaffold molecule after 10 repeated freeze and thaw cycles
Background
Antigen Description
Immunoglobulin G (IgG), is one of the most abundant proteins in human serum with normal levels between 8-17 mg/ml in adult blood. IgG is important for our defence against microorganisms and the molecules are produced by B-lymphocytes as a part of our adaptive immune response. The IgG molecule has two separate functions; to bind to the pathogen that elicited the response and to recruit other cells and molecules to destroy the antigen. The variability of the IgG pool is generated by somatic recombination and the number of specificities in an individual at a given time point is estimated to be 1011 variants.
Function
Antigen binding; protein binding.
Gene ID
3500
Synonyms
immunoglobulin heavy constant gamma 1 (G1m marker); IGHG1; Ig gamma 1 chain C region; Immunoglobin heavy constant gamma 1; Immunoglobulin G; IgG
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