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Anti-INS Protein A Scaffold

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Insulin Protein A scaffold AFB-35LY 1mg Please Inquiry
Product Detail
Cat
AFB-35LY
Product Overview
The Anti-Insulin Protein A Scaffold molecule was selected against recombinant human insulin (chain A and B). The Anti-Insulin Protein A Scaffold molecule is excellent for immunohistochemical staining of frozen and paraffin embedded tissue sections and an ideal affinity ligand for chromatography applications. The molecule is modified with a unique C-terminal cysteine for directed single-point chemical modification, facilitating labeling with fluorescent dyes, biotin or coupling to matrices.
Species Reactivity
human
Expression Host
E. coli
Applications
Affinity chromatography, immunohistochemical staining of frozen and paraffin embedded tissue sections.
Specificity
Anti-Insulin Protein A scaffold molecule binds to human, mouse and rat insulin.
Molecular Weight
14.0 kDa
Storage
At +4°C is recommended for lyophilized protein. For reconstituted protein in physiological buffer, short-term storage at +4°C is recommended. For long-term storage, the protein solution should be aliquoted and then stored at -20°C. There is no decrease in
Background
Antigen Description
The 5.7 kDa polypeptide hormone insulin is structured as two polypeptide chains, the 21 amino acid A chain and the 30 amino acid B chain, linked by two disulphide bonds. Insulin is synthesized in the beta cells of the islets of Langerhans in the pancreas as a prohormone; proinsulin that is later transformed by proteolytic action into the active hormone. Insulin excerts multiple actions throughout the body to regulate the energy metabolism. Its anabolics action includes build-up and storage of glycogen and fat.
Function
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Gene ID
3630
Synonyms
INS; insulin; ILPR; IRDN; IDDM2; MODY10; IN; proinsulin; Insulin B chain; Insulin A chain; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
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