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Anti-INS Protein A Scaffold

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Insulin Protein A scaffold AFB-10LY 1mg Please Inquiry
Product Detail
Cat
AFB-10LY
Species Reactivity
Human
Expression Host
E. coli
Specificity
This product recognises insulin.
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Defects in INS are the cause of familial hyperproinsulinemia (FHPRI).
Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2). IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM). PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10). MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Function
Hormone activity; hormone activity; hormone activity; insulin receptor binding; insulin receptor binding; insulin-like growth factor receptor binding; protein binding.
Gene ID
3630
Synonyms
INS; insulin; ILPR; IRDN; IDDM2; MODY10; IN; proinsulin; Insulin B chain; Insulin A chain; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
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