Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

Etrolizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Integrin alpha 4 beta 7 Therapeutic Antibody TAB-135 1mg Please Inquiry
Product Detail
Cat
TAB-135
Product Overview
Recombinant monoclonal antibody to integrin alpha 4 beta 7. Etrolizumab is a humanized monoclonal antibody designed for the treatment of inflammatory bowel disease.
Target
Integrin alpha 4 beta 7
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
1044758-60-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) and human integrin alpha-E/beta-7 (HML-1 antigen)); humanized rat monoclonal rhuMAb Beta7 des-447-lysine(CH3107K)-γ1 heavy chain (220-214")-disulfide with humanized rat monoclonal rhuMAb Beta7 kappa1 light chain, dimer (226-226"":229-229"")-bisdisulfide
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
Molecular Weight
144100
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer"s patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer"s patches and intestinal lamina propria.
Function
fibronectin binding; protein binding; receptor activity;
Gene ID
3676
Synonyms
ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); CD49D; integrin alpha-4; CD49d; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 subunit; IA4; MGC90518;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved