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imalumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human MIF Therapeutic Antibody TAB-H41 1mg Please Inquiry
Product Detail
Cat
TAB-H41
Product Overview
Recombinant human antibody to Human MIF
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, IHC and most other immunological methods.
CAS
1430205-07-4
Specificity
MIF (macrophage migration inhibitory factor, GIF, GLIF, glycosylation-inhibiting factor) [Homo sapiens]
Protein Construction
gamma1 heavy chain (1-448) [Homo sapiens VH (IGHV3-23*01 (92.80%) – (IGHD) – IGHJ3*01) [8.8.11] (1-118) – IGHG1*03 (CH1 (119-216),hinge (217-231), CH2 (232-341), CH3 (342-446), CHS (447-448)) (119-448)], (221-214') – disulfide withkappa light chain (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (85.30%) -IGKJ4*01) [6.3.9] (1'-107') -IGKC*01 (108'-214')]; dimer (227-227'':230-230'') – bisdisulfide
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Background
Antigen Description
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Function
cell surface binding; chemoattractant activity; cytokine activity; cytokine receptor binding; dopachrome isomerase activity; isomerase activity; phenylpyruvate tautomerase activity; protein binding; receptor binding;
Gene ID
4282
Synonyms
MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor); GLIF; macrophage migration inhibitory factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase; MMIF;
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