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Cantuzumab ravtansine

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human MUC1 Therapeutic Antibody TAB-173 1mg Please Inquiry
Product Detail
Cat
TAB-173
Product Overview
Recombinant monoclonal antibody to MUC1. Cantuzumab ravtansine is a humanized monoclonal antibody designed for the treatment of cancers. The antibody cantuzumab is linked to a cytotoxic agent, ravtansine.
Target
MUC1
Type
IgG1 - kappa
Immunogen
Synthetic peptide, corresponding to residues from the C-terminus of Human MUC1.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
868747-45-9
Specificity
Tested positive against native human antigen.
Protein Construction
Inmunoglobulina G1-kappa, anti-[Homo sapiens glicano sialilo de MUC1, asociado al tumor (CA242, antígeno del cancer 242)] anticuerpo monoclonal humanizado conjugado con el maitansinoide DM4
Predicted N terminal
H chain: QVQLVQS; L chain: DIVMTQS
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Function
RNA polymerase II core promoter proximal region sequence-specific DNA binding; p53 binding; protein binding; transcription cofactor activity;
Gene ID
4582
Synonyms
MUC1; mucin 1, cell surface associated; mucin 1, transmembrane , PUM; mucin-1; CD227; PEM; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; EMA; PUM; KL-6; MAM6; PEMT; H23AG; MUC-1; MUC-1/X; MUC1/ZD; MUC-1/SEC;
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