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Tanezumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human NGF Therapeutic Antibody TAB-111 1mg Please Inquiry
Product Detail
Cat
TAB-111
Product Overview
Recombinant monoclonal antibody to NGF. Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor, as a treatment for pain.
Target
NGF
Type
IgG2
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
880266-57-9
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G2, anti-(human nerve growth factor) humanized mouse monoclonal RN624 (Lys71,Ser330,Ser331)gamma2 heavy chain (135-214")-disulfide with kappa light chain (223-223"":224-224"":227-227"":230-230"")-tetrakisdisulfide dimer
Predicted N terminal
H chain: QVQLQES; L chain: DIQMTQS
Molecular Weight
145400
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
Function
growth factor activity; nerve growth factor receptor binding; receptor signaling protein activity;
Gene ID
4803
Synonyms
NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor; nerve growth factor, beta subunit; HSAN5; Beta-NGF; MGC161426; MGC161428;
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