Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

tarextumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human NOTCH2 Therapeutic Antibody TAB-H67 1mg Please Inquiry
Product Detail
Cat
TAB-H67
Product Overview
Recombinant human antibody to Human NOTCH2. Tarextumab (anti-Notch2/3, OMP-59R5) is a novel anti-cancer stem cell antibody identified by screening against the Notch3 receptor that binds to and prevents signaling through both the Notch2 and Notch3 receptors. Tarextumab has been shown in preclinical models to have broad-spectrum anti-tumor activity via inhibition of cancer stem cell growth, and promoting cell differentiation, as well as disrupting tumor angiogenesis by inhibiting vascular pericytes.
Type
IgG2 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
1359940-55-8
Specificity
NOTCH2 (notch 2) [Homo sapiens] ;
Protein Construction
gamma2 heavy chain (1-441) [Homo sapiens VH (IGHV3-66*01 (93.90%) – (IGHD) – IGHJ6*01 T123>L (110)) [8.8.8] (1-115) – IGHG2*01 (CH1(116-213), hinge (214-225), CH2 (226-334), CH3 (335-439), CHS (440-441)) (116-441)], (129-215') – disulfide withkappa light chain (1'-215') [Homo sapiens V-KAPPA (IGKV3-20*02 (94.40%) – IGKJ1*01) [7.3.9] (1'-108') – IGKC*01 (109'-215')]; dimer (217-217'':218-218'':221-221'':224-224'') – tetrakisdisulfide
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Background
Antigen Description
The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch4has a number of structural and functional differences.The binding of
Function
calcium ion binding; protein binding; receptor activity;
Gene ID
4853
Synonyms
NOTCH2; notch 2; Notch (Drosophila) homolog 2 , Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Notch homolog 2; hN2; AGS2; HJCYS;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved