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bococizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human PCSK9 Therapeutic Antibody TAB-H10 1mg Please Inquiry
Product Detail
Cat
TAB-H10
Product Overview
Recombinant Humanized (from mouse) antibody to Human PCSK9. Bococizumab (codenamed RN316)is a monoclonal antibody against PCSK9 designed to reduce LDL cholesterol
Type
IgG2 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, IHC and most other immunological methods.
CAS
1407495-02-6
Specificity
PCSK9(proprotein convertase subtilisin/kexin type 9, neural apoptosis-regulated convertase 1, NARC1, NARC-1, proproteine convertase 9, PC9) [Homo sapiens]
Protein Construction
Pfizer is referring to this as bococizumab (Oct 2013) but that name has yet to appear in INN or USAN listsgamma2 heavy chain (1-444) [humanized VH (Homo sapiens IGHV1-46*01 (90.80%) – (IGHD) – IGHJ1*01 L123>T (113)) [8.8.11] (1- 118) – Homosapiens IGHG2*01 (CH1 (119-216), hinge (217-228), CH2 A115>S (327), P116>S (328) (229-337), CH3 (338-442), CHS (443-444)) (119-444)], (132-214')-disulfidekappa light chain (1'- 214') [humanized V-KAPPA (Homo sapiens IGKV1 -13*02 (91.00%) – IGKJ2*01) [6.3.9] (1'-107') – Homo sapiens IGKC*01(108'-214')]; dimer (220-220":221-221":224-224":227-227") -tetrakisdisulfide
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Background
Antigen Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
353175
Synonyms
PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;
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