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Olaratumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human PDGF-R alpha Therapeutic Antibody TAB-192 1mg Please Inquiry
Product Detail
Cat
TAB-192
Product Overview
Recombinant monoclonal antibody to PDGF-R alpha. Olaratumab is a monoclonal antibody which is for the treatment of solid tumors. It is directed against the platelet-derived growth factor receptor alpha.
Target
PDGF-R alpha
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
1024603-93-7
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens PDGFRA (plateletderivedgrowth factor receptor alpha subunit, CD140a, PDGFR2)],Homo sapiens monoclonal antibody
Predicted N terminal
H chain: QLQLQES; L chain: EIVLTQS
Molecular Weight
147200
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
Function
ATP binding; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor
Gene ID
5156
Synonyms
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor alpha; CD140a; PDGFR2; PDGFR-alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; CD140A; PDGFR-2; RHEPDGFRA; MGC74795;
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