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Atinumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human RTN-4 Therapeutic Antibody TAB-242 1mg Please Inquiry
Product Detail
Cat
TAB-242
Product Overview
Recombinant monoclonal antibody to RTN-4. Atinumab is an immunomodulator. It binds to reticulon 4.
Target
RTN-4
Type
IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, Neut, ELISA, IF, IP, FuncS, FC and most other immunological methods.
CAS
1226761-65-4
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4-kappa, anti-[Homo sapiens RTN4 (reticulon 4, neurite outgrowth inhibitor, NOGO), isoform A], Homo sapiens monoclonal antibody
Predicted N terminal
H chain: EVQLVES; L chain: EIVLTQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Function
protein binding; protein complex binding;
Gene ID
57142
Synonyms
RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545;
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