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Blosozumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human SOST Therapeutic Antibody TAB-115 1mg Please Inquiry
Product Detail
Cat
TAB-115
Product Overview
Recombinant monoclonal antibody to SOST. Blosozumab binds SOST, a negative regulator of osteoblast activity. Blocking SOST activity can lead to increased bone density.
Target
SOST
Type
IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
1132758-87-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4, anti-(human sclerostin) (human-Mus musculus monoclonal heavy chain), disulfide with human-Mus musculus monoclonal Kappa-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DIQMTQS
Molecular Weight
144630
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Function
heparin binding; protein binding; transcription factor binding;
Gene ID
50964
Synonyms
SOST; sclerostin; sclerosteosis; VBCH;
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