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Satumomab Pendetide

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TAG72 Therapeutic Antibody (OncoScint CR103) TAB-002 1mg Please Inquiry
Product Detail
Cat
TAB-002
Product Overview
Recombinant monoclonal antibody to Human TAG72. Indium (111In) satumomab pendetide (trade name OncoScint CR103) is a mouse monoclonal antibody which is used for cancer diagnosis. The antibody itself, satumomab, is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111.
Target
TAG72
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
CAS
138955-26-7
Trade name
oncoscint cr103
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1 (mouse monoclonal B72.3 anti-human glycoprotein TAG-72), disulfide with mouse monoclonal B72.3 light chain, dimer
Predicted N terminal
H Chain: QVQLQQSL Chain: DIQMTQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
This monoclonal antibody can be attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111 and binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Antigen Description
The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
Keywords
CA 72.4; TAG 72; Tumor associated Glycoprotein 72; OncoScint CR103; Satumomab Pendetide
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