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Certolizumab pegol

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNF alpha therapeutic Antibody Fab Fragment (Cimzia) TAB-034-F(P) 1mg Please Inquiry
Product Detail
Cat
TAB-034-F(P)
Product Overview
Recombinant antibody fragment Fab to TNF alpha. Certolizumab pegol is a monoclonal antibody directed against tumor necrosis factor alpha. More precisely, it is a PEGylated Fab' fragment of a humanized TNF inhibitor monoclonal antibody. Polyethylene glycol does not cross the placenta, so it should be safe in pregnancy.
Target
TNF alpha
Type
Fab'
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
428863-50-7
Trade name
cimzia
Specificity
Tested positive against native human antigen.
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
Molecular Weight
47750
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Function
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;
Gene ID
7124
Synonyms
TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha;
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