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Anti-TNF Protein A Scaffold

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNF-α Protein A scaffold AFB-37LY 1mg Please Inquiry
Product Detail
Cat
AFB-37LY
Product Overview
The Anti-TNF-α Protein A Scaffold molecule was selected against human TNF-α. The Anti-TNF-α Protein A Scaffold molecule is an ideal affinity ligand as a capture reagent in ELISA and as detection reagent in dot blot. The Anti-TNF-α Protein A Scaffold molecule is modified with a unique C-terminal cysteine for directed single-point chemical modification, facilitating labeling with fluorescent dyes, biotin or coupling to matrices.
Species Reactivity
human
Expression Host
E. coli
Applications
Suitable as capture reagent in ELISA and as detection reagent in dot blot.
Specificity
Anti-TNF-α Protein A scaffold molecule binds to human cytokine tumor necrosis factor α, TNF-α. Cross reactivity with other species has not been tested.
Molecular Weight
13.7 kDa
Storage
At +4°C is recommended for lyophilized protein. For reconstituted protein in physiological buffer, short-term storage at +4°C is recommended. For long-term storage, the protein solution should be aliquoted and then stored at -20°C. There is no decrease in
Background
Antigen Description
Human TNF-α (Tumour Necrosis Factor-alpha) is a nonglycosylated protein of 17 kD belonging to the TNF superfamily of cytokines. TNF-α is produced by activated macrophages and Tlymphocyte and forms trimers spontaneously. TNF-α shows a wide spectrum of biological activities that are mediated by binding to TNFRI and TNFRII receptors. Besides causing cytolysis and cytostasis of many tumour cell lines in vitro, TNF-α has an important role in host defences against pathogens. However, excess TNF-α seen in sepsis and diseases of autoimmune character, has severe pathological consequences and the neutralisation of TNF-α has been a successful treatment procedure for rheumatoid arthritis.
Function
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding
Gene ID
7124
Synonyms
DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor; APC1 protein; Cachectin; tumor necrosis factor-alpha; TNF, macrophage-derived; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNFalpha; TNF Monocyte Derived; TNF Superfamily Member 2; TNF superfamily, member 2; TNF, monocyte derived; TNFA; Tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor Precursor; Tumor necrosis factor, soluble form; Tumour Necrosis Factor Alpha
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