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Ozoralizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNF-alpha Therapeutic Antibody TAB-138 1mg Please Inquiry
Product Detail
Cat
TAB-138
Product Overview
Recombinant monoclonal antibody to TNF-alpha. Ozoralizumab is a humanized monoclonal antibody designed for the treatment of inflammatory diseases.
Target
TNF-alpha
Type
VH - VH' - VH
Immunogen
Full length native protein (purified) (Human).
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CAS
1167985-17-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin single chain VH-VH"-VH, trivalent bispecific anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamily member 2, TNFSF2, TNFA, TNF-alpha)] VH and anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)] VH", humanized Lama glama monoclonal antibody
Predicted N terminal
H chain: EVQLVES
Molecular Weight
38430
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Function
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;
Gene ID
7124
Synonyms
TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha;
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