Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

Ranibizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human VEGF therapeutic Antibody Fab Fragment (ranibizumab) TAB-012-F(E) 1mg Please Inquiry
Product Detail
Cat
TAB-012-F(E)
Product Overview
Recombinant monoclonal antibody Fragment Fab to Human VEGF. Ranibizumab (trade name ranibizumab) is a monoclonal antibody fragment (Fab) derived from the same parent mouse antibody as bevacizumab (bevacizumab). It is much smaller than the parent molecule and has been affinity matured to provide stronger binding to VEGF-A. It is an anti-angiogenic that has been approved to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), a common form of age-related vision loss.
Target
VEGF
Type
Fab - G1 - kappa
Immunogen
Purified intact human VEGF
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, IHC and most other immunological methods.
CAS
347396-82-1
Trade name
ranibizumab
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1, anti-(human vascular endothelial growth factor) Fab fragment
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Function
cell surface binding; chemoattractant activity; cytokine activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; growth factor activity; heparin binding; heparin binding; platelet-derived growth factor recep
Gene ID
7422
Synonyms
VEGFA; vascular endothelial growth factor A; vascular endothelial growth factor , VEGF; VEGF A; VPF; vascular permeability factor; VEGF; MVCD1; MGC70609;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved