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vanucizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human VEGFA Therapeutic Antibody TAB-H73 1mg Please Inquiry
Product Detail
Cat
TAB-H73
Product Overview
Recombinant Humanized antibody to Human VEGFA
Type
VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
1448221-05-3
Specificity
VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF) [Homo sapiens] ;
Protein Construction
"RG7221 is a bi-specific monoclonal antibody comprised of two different heavy chains and two different light chains. One arm of theantibody binds Angiopoietin-2 (Ang2) and the other is based on bevacizumab (bevacizumab), binding Vascular Endothelial Growth Factor A(VEGF-A). The antibody is designed to inhibit both VEGF-A and Ang2 simultaneously to offer superior clinical benefit compared to VEGF-A inhibition alone." – Roche pipelinegamma1 heavy chain anti-ANGPT2 (1-463) [Homo sapiens VH (Homo sapiens IGHV1-2*02 (100.00%) – (IGHD) – IGHJ3*02) [8.8.22] (1-129) – Homo sapiens IGKC*01 R1.4>A (130), T1.3>S (131) (130-236) IGHG1*01 hinge CH2 – CH3 – CHS (hinge 6-15 (237-246), CH2(247-356), CH3 Y5>C (365), T22>S (382), L24>A (384), Y86>V (423) (357-461), CHS (462-463)) (237-463)], (236-213') – disulfide withlight chain anti-ANGPT2 (1'-213') [glutaminyl-prolyl-glycyl (1'-3') – Homo sapiens V-LAMBDA (Homo sapiens IGLV3-21*02 (100.00%) –IGLJ1*01) [6.3.11] (4'-108') – linker seryl-seryl 109'-110') – Homo sapiens IGHG1*01 CH1 – hinge (CH1 (111'-208') – hinge (1-5) (209'-213')];gamma1 heavy chain anti-VEGFA (1-453) [humanized VH (Homo sapiens IGHV3-23*03 (76.80%) – (IGHD) – IGHJ4*01) [8.8.16] (1-123)Homo sapiens IGHG1*01 (CH1 (124-221), hinge (222-236), CH2 (237-346), CH3 S10>C (360), T22>W (372) (347-451), CHS (452-453))(124-453)], (226-214') – disulfide withkappa light chain anti- VEGFA (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1- 16*01 (88.40%) -IGKJ1*01) [6.3.9] (1'-107') – Homosapiens IGKC*01 (108'-214')]; dimer (242-232":245-235":365-360") – trisdisulfide
Purity
>95.0% as determined by analysis by RP-HPLC.
Background
Antigen Description
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene
Function
cell surface binding; chemoattractant activity; cytokine activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; growth factor activity; heparin binding; heparin binding; platelet-derived growth factor recep
Gene ID
7422
Synonyms
VEGFA; vascular endothelial growth factor A; vascular endothelial growth factor , VEGF; VEGF A; VPF; vascular permeability factor; VEGF; MVCD1; MGC70609;
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