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Caplacizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Von Willebrand Factor Therapeutic Antibody TAB-234 1mg Please Inquiry
Product Detail
Cat
TAB-234
Product Overview
Recombinant monoclonal antibody to Von Willebrand Factor. Caplacizumab (INN) is a humanized monoclonal that binds to VWF.
Target
Von Willebrand Factor
Type
VH - VH
Immunogen
Full length protein (Human)
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
CAS
915810-67-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin VH-linker-VH fragment, anti-[Homo sapiens VWF (von Willebrand factor) A1 domain], humanized monoclonal antibody; VH-linker-VH chain (1-259) [humanized VH (Homo sapiens IGHV3-23*04 (82.50%) -(IGHD)-IGHJ4*01 L123>Q [8.8.21] (1-128)) - trialanyl linker (129-131) -[humanized VH (Homo sapiens IGHV3-23*04 (82.50%) -(IGHD)-IGHJ4*01 L123>Q [8.8.21] (132-259) anti-von Willebrand factor
Predicted N terminal
EVQLVES
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Function
chaperone binding; collagen binding; glycoprotein binding; immunoglobulin binding; integrin binding; protease binding; protease binding; protein N-terminus binding; protein binding; protein homodimerization activity;
Gene ID
7450
Synonyms
VWF; von Willebrand factor; F8VWF; coagulation factor VIII VWF; VWD;
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