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Romosozumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human scleroscin Therapeutic Antibody TAB-116 1mg Please Inquiry
Product Detail
Cat
TAB-116
Product Overview
Recombinant monoclonal antibody to scleroscin. Romosozumab is a humanized monoclonal antibody designed for the treatment of osteoporosis.
Target
SOST
Type
IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
909395-70-6
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G2-kappa, anti-[Homo sapiens SOST (sclerostin)], humanized monoclonal antibody
Predicted N terminal
H chain: EVQLVQS; L chain: DIQMTQS
Molecular Weight
145900
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Function
heparin binding; protein binding; transcription factor binding;
Gene ID
50964
Synonyms
SOST; sclerostin; sclerosteosis; VBCH;
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