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Inclacumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human selectin P Therapeutic Antibody TAB-246 1mg Please Inquiry
Product Detail
Cat
TAB-246
Product Overview
Recombinant monoclonal antibody to selectin P. Inclacumab (INN) is a humanized monoclonal that binds to selectin P.
Target
selectin P
Type
IgG4 - kappa
Immunogen
CD62P transfected 300.19 cells (Human)
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
CAS
1256258-86-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4-kappa, anti-[Homo sapiens SELP (selectin P, CD62)], Homo sapiens monoclonal antibody
Predicted N terminal
H chain: EVQLVES; L chain: EIVLTQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Function
calcium-dependent protein binding; eukaryotic cell surface binding; fucose binding; glycoprotein binding; glycosphingolipid binding; heparin binding; lipopolysaccharide binding; oligosaccharide binding; protein binding; sialic acid binding; sugar binding;
Gene ID
6403
Synonyms
SELP; selectin P (granule membrane protein 140kDa, antigen CD62); GRMP, selectin P (granule membrane protein 140kD, antigen CD62); P-selectin; CD62; CD62P; GMP140; PADGEM; PSEL; GMP-140; granule membrane protein 140; granulocyte membrane protein; CD62 antigen-like family member P; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; GRMP; LECAM3; FLJ45155;
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