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anifrolumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-IFNAR Therapeutic Antibody TAB-722 1mg Please Inquiry
Product Detail
Cat
TAB-722
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to human interferon α/β receptor. Anifrolumab is a monoclonal antibody designed for the treatment of systemic lupus erythematosus.
Target
interferon α/β receptor
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
NSO mouse myeloma cells
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
CAS
1326232-46-5
Predicted N terminal
EVQLVQSG
Molecular Weight
145.12 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2.[2]It is a cell surface receptor. Binding of cytokine follows a JAK-STAT signaling pathway. Interferon stimulation results in an immunologic response that is especially associated with viruses.
Antigen Description
The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. It is a cell surface receptor.
Keywords
interferon-α/β receptor; IFNAR
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