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dalotuzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-IGF1R Therapeutic Antibody TAB-736 1mg Please Inquiry
Product Detail
Cat
TAB-736
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
Target
IGF1R
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
1005389-60-5
Predicted N terminal
QVQLQESG
Molecular Weight
146.4 kDa
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Introduction
Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
Antigen Description
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Function
ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleo
Gene ID
3480
Synonyms
IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
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