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guselkumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-IL23A Therapeutic Antibody TAB-752 1mg Please Inquiry
Product Detail
Cat
TAB-752
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to human IL23A. Guselkumab is a monoclonal antibody designed for the treatment of psoriasis.
Target
IL23A
Type
IgG1 - lambda
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
CAS
1350289-85-8
Predicted N terminal
EVQLVQSG
Molecular Weight
143.6 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Introduction
Guselkumab is a monoclonal antibody designed for the treatment of psoriasis.
Antigen Description
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
Function
cytokine activity; contributes_to interleukin-23 receptor binding;
Gene ID
51561
Synonyms
IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388;
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