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Alirocumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-PCSK9 Therapeutic Antibody TAB-719 1mg Please Inquiry
Product Detail
Cat
TAB-719
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to human PCSK9. Alirocumab is a human monoclonal antibody designed for the treatment of hypercholesterolemia. This therapeutic is also known by the codes REGN727 and SAR236553.
Target
PCSK9
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
CAS
1245916-14-6
Predicted N terminal
EVQLVESG
Molecular Weight
146.0 kDa
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Introduction
Alirocumab is a human monoclonal antibody designed for the treatment of hypercholesterolemia.
Antigen Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Gene ID
353175
Synonyms
PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;
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