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concizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-TFPI Therapeutic Antibody TAB-734 1mg Please Inquiry
Product Detail
Cat
TAB-734
Product Overview
Recombinant humanized antibody expressed in CHO binding to human TFPI. Concizumab is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
Target
TFPI
Type
IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
Predicted N terminal
EVQLVESG
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Introduction
Concizumab is a monoclonal antibody (mAb) against Tissue Factor Pathway Inhibitor (TFPI).
Antigen Description
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
Function
endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Gene ID
7035
Synonyms
TFPI; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); LACI; tissue factor pathway inhibitor; EPI; extrinsic pathway inhibitor; TFI; TFPI1; anti-convertin;
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