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Indium (111In) imciromab

DESCRIPTION CATALOG # SIZE PRICE
Anti-cardiac myosin Therapeutic Antibody (Myoscint) TAB-708 1mg Please Inquiry
Product Detail
Cat
TAB-708
Product Overview
Recombinant mouse monoclonal antibody Fab fragment expressed in CHO binding to human cardiac myosin. Indium (111In) imciromab is a mouse monoclonal antibody and was used for cardiac imaging, but withdrawn in 1993.
Target
cardiac myosin
Type
Mouse Fab IgG2a - kappa - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
Murine ascites, pepsin digestion
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
CAS
126132-83-0
Trade name
Myoscint
Molecular Weight
Approximately 47 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Introduction
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. Th
Antigen Description
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
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