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Chemical Linked Fabs'

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Chemical linked Fabs' is type of bispecific antibody formed by two chemically linked Fabs (fragments antigen-binding). These two Fab fragments are fromed by two different monoclonal antibodies and are linked by chemical linker such as a thioether. Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell, an Fc receptor on a macrophage, for instance. In this way, tumour cells are attached to immune cells, leading to their destruction. The figure shows an example of chemically linked Fabs: two Fab fragments are linked with a thioether, resulting in a F(ab')2. The molecule is bound to a tumour cell via the tumour antigen CD30 and to a macrophage via an Fc receptor.

CHEMICAL LINKED Fabs (BsAb)

Scientists in Creative Biolabs have successfully established the method to produce custom bispecific antibody according to client's requirement. If interested, please contact us.




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