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DNA Immunization-based Native™ Antibody Discovery Service

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In terms of comprehensive DNA immunization strategies, Creative Biolabs can discover naturally paired antibodies that specifically bind to the target with naïve conformation. Our scientists will choice the most appropriate DNA immunization strategy to induce immune response to the in vivo expressed target and perform our Native™ antibody discovery platform to develop monoclonal antibodies through B cell sorting technology.

Compared with the conventional protein-based immunization methods, DNA immunization offers a unique and powerful approach for antibody discovery and development. Instead of the recombinant protein production and purification, DNA immunization strategies can enable the host animal cells to express the target of interest in vivo, which is effective at generating antibodies against conformation-sensitive proteins or other challenging targets. To meet our clients’ specific project objective, scientists from Creative Biolabs have developed a series of genetic-based immunization strategies, which including but not limited to:


Moreover, the unique Native™ antibody discovery platform developed by Creative Biolabs can further assist the antibody discovery process and contribute to isolating high-affinity antibodies with naturally paired heavy- and light-chain. This platform is based on the antigen-specific B lymphocytes cytometry technology, which can avoid both hybridoma fusion partner limitation and combinatorial display processes. This platform can be performed to a broad range of host species (e.g. rodents, camelid, sheep, monkeys, dogs, etc.) and allows our scientists to select a large number of antibody candidates from the host. The isolated native antibodies take advantages of their natural pair and have gone through the in vivo affinity maturation to indicate higher solubility or other desired biophysical characteristics. Currently, the Native™ antibody discovery platform has emerged as one of the most important and efficient antibody discovery technologies, especially for sampling the natural antibody repertoire as therapeutic applications.

DNA Immunization-based Native™ Antibody Discovery Service

Advantages of DNA Immunization-based Native™ Antibody Discovery Service


As an alternative to this Native™ platform, Creative Biolabs also provides conventional antibody discovery methods based on our DNA immunization strategies, such as phage display and hybridoma. Our scientists are pleased to work closely for your specific project and tailor the best-fit proposal to meet your goals.

Reference

  1. Shuying Liu, Shixia Wang, & Shan Lu. (2016). DNA immunization as a technology platform for monoclonal antibody induction. Emerging Microbes & Infections, 5(4), E33.



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