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De Novo Biosimilar Monoclonal Antibodies Sequencing Service

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Creative Biolabs provides monoclonal antibodies sequencing service for biosimilar development, which provides full sequence coverage of the antibodies with 100% accuracy. Functional biosimilar monoclonal antibodies can be sequenced by subunit with 100% coverage as well as excellent precision based on our world’s number one platform of de novo antibody sequencing using our proprietary Database Assisted Shotgun Sequencing (DASS) technology, all of which has been proved with abundant successful cases with 100% accuracy.

Biosimilars are protein equivalents of generic chemical drugs that come onto the market after patent expiration of an originator therapeutic protein. A major concern with biosimilars is that undetectable differences compared with originator products might lead to unexpected immunogenicity in patients. Biosimilar monoclonal antibodies (mAbs) are making their way onto the drug market. Several researchers have indicated that similarity testing between originator mAbs and biosimilar mAbs is more difficult than similarity testing between non-mAb originator and biosimilar products. Between 2003 and 2011, about 40% of all requests for scientific advice EMA received were for biosimila rmAbs, indicating the extensive interest in developing these products. This is not surprising as the monoclonal antibody products on the market are very profitable and can generate huge revenues.

<em>De Novo</em> Biosimilar monoclonal antibodies Sequencing Service

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