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De Novo TCR (T Cell Receptor) Sequencing Service

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Creative Biolabs is pleased to introduce an unparalleled de novo TCR (T Cell Receptor) Sequencing service, which has been developed based on our world-leading platform of de novo antibody sequencing using our proprietary Database Assisted Shotgun Sequencing (DASS). Soluble and functional human or mouse TCRs in monomer and multivalent form can be sequenced by subunit with 100% coverage of V(D)JC regions as well as excellent accuracy.

<em>De Novo</em> TCR (T-cell Receptor) Sequencing Service

TCRs have facilitated a detailed analysis of TCR/MHC-peptide interactions by specifically targeting MHC-peptide complexes. Multivalent TCR complexes comprising two or more TCRs are significantly enhanced in binding capability, which made them powerful tools in tracking or targeting cells presenting particular antigens in vitro or in vivo, and thus they have considerable potential of becoming pharmaceutically acceptable formulations. However, since multivalent TCR complexes are preferably tetramers covalently linked by avidin/strepavidin in the form of biotinylated-TCRs, also the TCR alpha/beta chains may be stabilized by mutations or artificial tags, which made sequencing TCR by amino acid extremely difficult and even impossible by conventional strategy.

Relying on our experience in 500 de novo antibody sequencing projects with 100% success, our expert scientists have a deep understanding of immunological proteins, combined with our advanced Orbitrap mass facility and cutting-edge data mining algorithm, sequences of the multivalent TCR complexes can be accurately determined and distinguished from avidin/strepavidin & artificial tags, and without affected by biotinylation. Creative Biolabs is proud to be the first company that offers professional TCR sequencing services to satisfy our customer's requirements. Note that we also have strongest expertise in antibody sequencing field, antibodies from all species, isotypes and allotypes can be successfully sequenced with 50-100µg purified sample.




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