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Engineered Protein Scaffold Library Construction Service

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Creative Biolabs offers engineered protein scaffold library construction service. Our service has provided a strong foundation for the successful isolation and exploitation of high-affinity binders in the fields of research, diagnosis, and therapy. Creative Biolabs has developed trimer codon technology, which offers site-directed mutant library construction in a high-throughput and extremely precise way.

Engineered protein scaffolds Library Construction Service

Engineered protein scaffolds are invaluable tools for a vast range of biotechnological and pharmaceutical applications. Possibilities of engineered protein scaffolds have been explored in research, diagnostics and therapy in the last few years. Some scaffolds have focused on broadening their fields of application, while others have occupied their respective niche. The modular structure of these protein scaffolds and their favorable biophysical & chemical properties, such as small in size, high permeability through the cell membrane, lack of disulfide bonds within the molecule, high thermodynamic stability and lack of aggregation, not only allow the binding of a diverse set of targets in a specific manner and with high affinity, but also suggest the utilization of the rigid protein framework for generic engineering concepts, intracellular applications, for instance. By now, reports on the utilization of the engineered protein scaffolds have expanded to X-ray structure determination of binder/target complexes, imaging of cell surface markers and conjugation with drug payloads. Notably, these are also the classes where members have progressed to clinical trials.

Engineered protein display scaffolds, when specifically selected, can bind virtually to any target. Protein engineering, the prerequisite for the advent of all protein scaffolds, remains the driving force in this process. Devised to expand the range of applications of specific protein scaffolds, Creative Biolabs has developed trimer codon mutant library construction technology, which offers 100% precise mutant library construction with the expected size of over 1010.

Engineered protein scaffolds Library Construction Service

Our technology includes the services for:
Engineered Protein Scaffold Library Construction Service for Phage Display
Engineered Protein Scaffold Library Construction Service for Ribosome Display
Engineered Protein Scaffold Library Construction Service for mRNA Display
Engineered Protein Scaffold Library Construction Service for Cell Surface Display
Mammalia/Yeast Two-hybrid Library for Discovery of Protein Scaffolds Based Intrabodies

A
Affilin , Affimer , Affitin/Sac7d , Avian Pancreatic Polypeptide (APP) , Alzheimer’s Amyloid β-Protein Precursor Inhibitor (APPI) , Aptide , Avimer/Maxibody/Low-Density Lipoprotein Receptor (LDLR) Domain A

B
Bovine Pancreatic Trypsin Inhibitor (BPTI)/Aprotinin

C
Cellulose-Binding Domain (CBD) , The Second Family 4 Carbohydrate Binding Module (CBM4-2) , CH2 Domain (CH2D)/ Nanoantibody (nAb) , Charybdotoxin (CTX) , C-Type Lectin-like Domain (CTLD) , Cytochrome b562

D
Designed Ankyrin Repeat Proteins (DARPins)

E
Ecotin , The Ecballium elaterium Trypsin Inhibitor II (EETI-II)

G
GCN4 , Green Fluorescent Protein (GFP)

I
The Immunity Protein 9 (Im9) , Insect Defensin A , Intrabody

K
Knottins

L
Human Lipoprotein-Associated Coagulation Inhibitor Domain 1 (LACI-D1)/Tissue Factor Pathway Inhibitor-I (TFPI-I) , The Leech-Derived Tryptase Inhibitor (LDTI)

M
Min-23 , Monobody/Fibronectin Type III Domain (FN3) , The Mustard Trypsin Inhibitor 2 (MTI-2)

N

Neocarzinostatin (NCS)

P
The Periplasmic Binding Protein (PBP) , PDZ Domain , The Plant Homeodomain (PHD) Finger , pre-B-Cell Receptor (pre-BCR) , Protein A Scaffold , Pancreatic Secretory Trypsin Inhibitor (PSTI)/Tumor-Associated Trypsin Inhibitor (TATI)/Serine Protease Inhibitor Kazal-type 1 (SPINK1) , pVIII

S
Sunflower Trypsin Inhibitor (SFTI) , Src Homology 2 (SH2) and Src Homology 3 (SH3) , Staphylococcal Nuclease

T
TEM-1 β-lactamase , Tendamistat , Thioredoxin (TrxA) , Tetratricopeptide Repeat (TPR) , Trans-body/Human Serum Transferrin (hTF)

W
WW Domain

Z
Zinc Finger

Others
α2p8




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