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Membrane Protein Platform

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Creative Biolabs has established custom membrane protein and membrane protein antibody production platforms for antibody discovery.

Membrane proteins, actually, are a kind of proteins acting as ion channels, receptors and transporters, which enable the cells to transport environmental signals across the biological membranes. Membrane proteins can be classified into two categories, integral (intrinsic) and peripheral (extrinsic) membrane proteins—based on the nature of the membrane-protein interactions (Figure 1).

Membrane Protein Platform Figure 1. Schematic of membrane proteins in biological membrane. (Molecular cell biology, 4th edition)

Integral membrane proteins, have one or more segments that are embedded in the phospholipid bilayer, of which most span the entire phospholipid bilayer. These transmembrane proteins contain one or more hydrophobic membrane-spanning domains (α helices or multiple β strands), extending into the aqueous environment. Peripheral membrane proteins, do not interact with the hydrophobic core of the phospholipid bilayer. Instead they are commonly bound to the plasma membrane by indirect interactions with integral membrane proteins or by dirct interactions with lipid polar head groups. Peripheral proteins are located to the cytosolic face of the plasma membrane, playing a role in signal transduction. Other peripheral proteins, including certain proteins of the extracellular matrix, are localized to the outer (exoplasmic) surface of the plasma membrane.

It has been proven that membrane proteins perform a wide range of functions in cell growth, cell–cell communication (signaling transduction), differentiation, flow of information, metabolism, and migration. Defects in some membrane proteins can lead to diseases, such as cancer, therefore, membrane proteins represent nearly 50% of the targets of therapeutic research. It is very difficult to study membrane proteins due to their naturally low expression levels, although, the study of the structures of membrane proteins is a hot-spot issue all over the world because this will help to better understand the functions of these membrane proteins. Creative Biolabs has many unparalleled expression systems to obtain high-yield and native conformational membrane proteins.

Except for membrane protein production, Creative Biolabs can provide customized membrane protein antibody production services. Solubilization of the membrane protein immunogens with detergents may lead to major conformational changes, making their testing with monoclonal antibodies by immune blot and ordinary immunoprecipitation difficult. Using unique MPAT™ and MEAD™ technoligies, Creative Biolabs is specialized in membrane protein and its antibody production services. Please feel free to contact us for a detailed quote.

References:
A. M. Seddon, et al. (2004). Membrane proteins, lipids and detergents: not just a soap opera. Biochim. Biophy. Acta., 1666(1-2): 105-117.
Membrane protein. (https://en.wikipedia.org/wiki/Membrane_protein).
Membrane proteins. Molecular Cell Biology. 4th edition. Section 3.4.




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