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Anti-APP Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human APP Antibody MOM-18228 1mg Please Inquiry
Product Detail
Cat
MOM-18228
Product Overview
Recombinant Humanized (from mouse) Antibody binds selectively to Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
Target
Abeta
Type
Humanized (from mouse) IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens amyloid-beta (Abeta) peptide soluble monomer], humanized monoclonal antibody; gamma1 heavy chain [humanized VH (Homo sapiens IGHV3-23*04 (87.60%) -(IGHD)-IGHJ4*01) [8.8.5] (1-112) -Homo sapiens IGHG1*01, CH3 K13
Predicted N terminal
H chain: EVQLVES; L Chain: DVVMTQS
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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