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Anti-APP Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human APP Antibody MOM-18229 1mg Please Inquiry
Product Detail
Cat
MOM-18229
Product Overview
Recombinant Human Antibody is against Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
Target
Abeta
Type
Human IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti-(human beta-amyloid peptides A beta42 and A beta40) human monoclonal antibody; gamma1 heavy chain (Homo sapiens VH-IGHG1) (229-215')-disulfide with kappa light chain (Homo sapiens V-KAPPA-IGKC); (235-235":238-238")-bisdisulfide dim
Predicted N terminal
H chain: QVELVES; L Chain: DIVLTQS
Purity
Purity >95% by SDS-PAGE.
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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