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Anti-C5 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human C5 Antibody Fab Fragment MOM-18008-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18008-F(E)
Product Overview
Recombinant Humanized (from mouse) Antibody Fab Fragment binds selectively to Human C5, expressed in Chinese Hamster Ovary cells(CHO)
Target
C5
Type
Fab Fragment based on Humanized (from mouse) IgG2 / G4 - kappa
Immunogen
Human C5 protein emulsified with complete Fraud's adjuvant
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa). C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain).
Function
C5a anaphylatoxin chemotactic receptor binding; chemokine activity; endopeptidase inhibitor activity; receptor binding;
Gene ID
727
Synonyms
C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298;
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