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Anti-CD22 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human CD22 Antibody Fab Fragment MOM-18047-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18047-F(E)
Product Overview
Recombinant Mouse Antibody Fab Fragment is against Human CD22, expressed in Chinese Hamster Ovary cells(CHO)
Target
CD22
Type
Fab Fragment based on Mouse Fab' - G2a - kappa
Immunogen
A combination of recombinant human CD22 extracellular 25 domain and CHO ceIls engineered to express full-length human CD22 on the ceIl surface
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G2a, anti-(human CD22 (antigen))Fab fragment (mouse monoclonal IMMU-LL2 g2a-chain), disulfide with mousemonoclonal IMMU-LL2 light chain
Predicted N terminal
H chain: EVQLVQS; L Chain: EIVLTQS
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.
Function
protein binding; sugar binding;
Gene ID
933
Synonyms
CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020;
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