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Anti-CD40 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human CD40 Antibody Fab Fragment MOM-18152-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18152-F(E)
Product Overview
Recombinant Humanized (from mouse) Antibody Fab Fragment is directed against Human CD40, expressed in Chinese Hamster Ovary cells(CHO)
Target
CD40
Type
Fab Fragment based on Humanized (from mouse) IgG1
Immunogen
Recombinant protein of extracellular domain of CD40
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Predicted N terminal
H chain: EVQLQQS; L Chain: DVVVTQT
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Function
enzyme binding; protein binding; receptor activity; signal transducer activity;
Gene ID
958
Synonyms
CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50; p50; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CDW40; TNFRSF5; MGC9013;
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