|Recombinant Anti-Human CD40LG Antibody
- Product Overview
- Recombinant Humanized (from mouse) Antibody is bind to Human CD40L, expressed in Chinese Hamster Ovary cells(CHO)
- Humanized (from mouse) IgG1 - kappa
- Animals were immunized with D1.1 cells.
- Species Reactivity
- Expression Host
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- Tested positive against native antigen.
- Protein Construction
- Immunoglobulin G1, (anti-human CD40 ligand) (human-mouse monoclonal 5c8 gamma 1-chain), disulfide with human-mouse monoclonal 5c8 kappa-chain, dimer
- Predicted N terminal
- H Chain: QVQLVQS; L Chain: DIVLTQS
- Purity >95% by SDS-PAGE.
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
- Antigen Description
- Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
- CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;
- Gene ID
- CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;
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