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Anti-GD3 ganglioside Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human GD3 ganglioside Antibody MOM-18131 1mg Please Inquiry
Product Detail
Cat
MOM-18131
Product Overview
Recombinant Chimeric (mouse/human) Antibody is against Human GD3 ganglioside, expressed in Chinese Hamster Ovary cells(CHO)
Target
GD3 ganglioside
Type
Chimeric (mouse/human) IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti-(GD3 ganglioside) (human-mouse monoclonal KM871 g1-chain), disulfide withhuman-mouse monoclonal KM871 k-chain, dimer
Predicted N terminal
H chain: EVQLVES; L Chain: DIQMTQS
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Introduction
This is a chimeric monoclonal antibody being developed for the treatment of malignant melanoma.
Antigen Description
Almost all melanomas, astrocytomas, a proportion of sarcomas, a small number of carcinomas, some nevi, as well as normal melanocytes express GD3 antigen. It is one of the most important markers for malignant melanoma. Antibodies to the GD3 ganglioside can induce partial remission of tumor growth in animals as well as in Humans via enhancement of cytotoxic and proliferative response of lymphocytes.
Keywords
GD3 ganglioside
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