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Anti-IL2RA Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human IL2RA Antibody Fab Fragment MOM-18023-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18023-F(E)
Product Overview
Recombinant Humanized (from mouse) Antibody Fab Fragment is specific to Human CD25, expressed in Chinese Hamster Ovary cells(CHO cells)
Target
CD25
Type
Fab Fragment based on Humanized (from mouse) IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express CD25 in humans. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.
Function
drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;
Gene ID
3559
Synonyms
IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;
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