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Anti-IL2RA Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human IL2RA Antibody MOM-18004 1mg Please Inquiry
Product Detail
Cat
MOM-18004
Product Overview
Recombinant Chimeric (mouse/human) Antibody specifically binds to Human CD25, expressed in Chinese Hamster Ovary cells(CHO)
Target
CD25
Type
Chimeric (mouse/human) IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti-(human interleukin 2 receptor) (human-mouse monoclonal clone 1H4 g1-chain), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer
Predicted N terminal
H chain: QLQQSGT; L Chain: QIVSTQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express CD25 in humans. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.
Function
drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;
Gene ID
3559
Synonyms
IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;
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