|Recombinant Anti-Human MUC1 Antibody
- Product Overview
- Recombinant Humanized (from mouse) Antibody is specific to Human MUC1, expressed in Chinese Hamster Ovary cells(CHO)
- Humanized (from mouse) IgG1 - kappa
- Synthetic peptides conjugated with KLH and mixed with complete Freund's adjuvant
- Species Reactivity
- Expression Host
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
- Tested positive against native antigen.
- Protein Construction
- Immunoglobulin G1, anti-(mucin CanAg) (human-mouse monoclonal C242 heavy chain), disulfide with human-mouse monoclonal C242 light chain, dimer,
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Store at -20°C. Avoid multiple freeze/thaw cycles.
- Antigen Description
- The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
- RNA polymerase II core promoter proximal region sequence-specific DNA binding; p53 binding; protein binding; transcription cofactor activity;
- Gene ID
- MUC1; mucin 1, cell surface associated; mucin 1, transmembrane , PUM; mucin-1; CD227; PEM; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; EMA; PUM; KL-6; MAM6; PEMT; H23AG; MUC-1; MUC-1/X; MUC1/ZD; MUC-1/SEC;
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