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Anti-RTN4 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human RTN4 Antibody Fab Fragment MOM-18242-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18242-F(P)
Product Overview
Recombinant Human Antibody Fab Fragment is against Human RTN-4, expressed in E.Coli
Target
RTN-4
Type
Fab Fragment based on Human IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
E.Coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Predicted N terminal
H chain: EVQLVES; L Chain: EIVLTQS
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
At -20°C for one year.
Background
Antigen Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Function
protein binding; protein complex binding;
Gene ID
57142
Synonyms
RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545;
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