Anti-SOST Antibody Fab
|Recombinant Anti-Human SOST Antibody Fab Fragment
- Product Overview
- Recombinant Humanized (from mouse) Antibody Fab Fragment is against Human SOST, expressed in E. coli
- Fab Fragment based on Humanized (from mouse) IgG4 - kappa
- The details of the immunogen for this antibody are not available.
- Species Reactivity
- Expression Host
- E. coli
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Tested positive against native antigen.
- Predicted N terminal
- H chain: QVQLVQS; L Chain: DIQMTQS
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Antigen Description
- Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
- heparin binding; protein binding; transcription factor binding;
- Gene ID
- SOST; sclerostin; sclerosteosis; VBCH;
- Download Datasheet:
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