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Anti-SOST Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human SOST Antibody Fab Fragment MOM-18115-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18115-F(P)
Product Overview
Recombinant Humanized (from mouse) Antibody Fab Fragment is against Human SOST, expressed in E. coli
Target
SOST
Type
Fab Fragment based on Humanized (from mouse) IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Predicted N terminal
H chain: QVQLVQS; L Chain: DIQMTQS
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Function
heparin binding; protein binding; transcription factor binding;
Gene ID
50964
Synonyms
SOST; sclerostin; sclerosteosis; VBCH;
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