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Anti-SOST Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human SOST Antibody MOM-18115 1mg Please Inquiry
Product Detail
Cat
MOM-18115
Product Overview
Recombinant Humanized (from mouse) Antibody is specific to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)
Target
SOST
Type
Humanized (from mouse) IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G4, anti-(human sclerostin) (human-Mus musculus monoclonal heavy chain), disulfide with human-Mus musculus monoclonal Kappa-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L Chain: DIQMTQS
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Function
heparin binding; protein binding; transcription factor binding;
Gene ID
50964
Synonyms
SOST; sclerostin; sclerosteosis; VBCH;
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