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Anti-SOST Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human SOST Antibody MOM-18116 1mg Please Inquiry
Product Detail
Cat
MOM-18116
Product Overview
Recombinant Humanized (from mouse) Antibody binds selectively to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)
Target
SOST
Type
Humanized (from mouse) IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G2-kappa, anti-[Homo sapiens SOST (sclerostin)], humanized monoclonal antibody
Predicted N terminal
H chain: EVQLVQS; L Chain: DIQMTQS
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Function
heparin binding; protein binding; transcription factor binding;
Gene ID
50964
Synonyms
SOST; sclerostin; sclerosteosis; VBCH;
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